Good tool for looking at amino acid conservation; runs slow with many users at once (may

present a problem in a larger class), using gallery –>K+ channel -I  can see core of conserved residues and less conserved loops.  Idea for student module: start with DNA that contains mutations, students translate, figure out what protein they have by searching database with blast, build MSA, look up structure and try to predict whether the student’s mutation has will affect function/how severe.  May be able to then go to OMIM and link to disease/human health relevance.

 

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