IGF2R Consurf


We, Dawn, Jen, and I, looked at Insulin Growth Factor 2 bound to the IGF2R. This is the conservation of the receptor. There weren’t many homologs, only 28 found to align well enough. Therefore we have many amino acids for which there isn’t enough information to determine the conservation. From the structure, you can see that the interface with IGF2 isn’t well conserved (red arrow), however the carbohydrate–binding surface (Blue arrow) is moderately conserved. This implies the evolution that is known in that IGF2R has evolved from a carbohydrate binding receptor that took on a new role of binding IGF2.


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