Archive for category Structural Biology #1

Protein visualization (Rachel / Thomas)

Solved crystal structure of BRCA1 BRCT (made in Jmol):

Electrostatic map of BRCA1 BRCT (made in Pymol):

Sequence of BRCA1 BRCT showing features such as beta strands and alpha helices:

The structure has a diameter of ~27 A.  ~55 A in length.

There are a variety of secondary structures including beta turns, beta strands and alpha helices.

BRCA1 is composed of 215 residues.

Conserf run (MSA):

Dark purple regions are conserved.  Notice ligands binding in that region.

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Factor Va

Here’s my structural image of a model of bovine factor Va. Colors indicate the domains and the orange spheres are the carbohydrates.