We decided on Leptin, a hormone involed with appetite suppression, because obesity is an increasing problem in affluent countries and we are in one. There is one disulfide bridge within this protein, and 4 alpha helices adjacent to each other with multiple leucine residues that are highly conserved (as verified by Consurf). Also, there is a random chain that is not highly conserved except for a tail region, potentially meaning that this tail region is important for the protein’s function.