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Consurf

alignment
Goals for this session:

    Connect what you have observed with sequence alignments and trees to protein structures.
    Specifically:

  • Map a sequence alignment on a structure
  • Interpret the results — Where are the rapidly changing residues? Where are the slowly changing residues located?

Tools:

Project:

    In groups – continue working either with the alignments you made yesterday (requires at least 6 sequences) for which a protein structure exists – or search the PDB for your favorite protein and use it to view a preformed multiple sequence alignment (MSA) from Consurf.

Post (to either the blog or project page) a report including:

  • A brief intro to your protein
  • Bibliographic reference
  • Species used in the alignment
  • An image
  • Your interpretation of the results
  • To questions you are still working on

consurf