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Wnt protein

By Xiaomin and Jianzhuang

Introduction: Wnt proteins form a family of highly conserved secreted signaling molecules

that regulate cell-to-cell interactions during embryogenesis. Wnt proteins bind to

receptors of the Frizzled and LRP families on the cell surface. Mutations in Wnt genes or

Wnt pathway components lead to specific developmental defects, while various human

diseases, including […]

Consurf Activity Cytochrome C

Goup: Ben Ernest, Joel Bucci, Letitia Olson

Intro: Cytochrome C oxidase is an enzyme in the electron transport chain that catalyzes electron transfer to reduce oxygen to water. This reaction produces protons, which are then used to power the ATP synthases

Reference: Axel Harrenga and Hartmut Michel. The Cytochrome c Oxidase from Paracoccus denitrificans Does […]

Protein Luciferase: Lenora & Elizabeth

Intro:

This particular enzyme is an oxidative enzyme that imparts bioluminescence to the firefly Photinus pyralis. In research, the enzyme is used to study anesthetic-protein interactions.

Ref:

Structural basis for the inhibition of firefly luciferase by a general anesthetic. Franks, N.P., Jenkins, A., Conti, E., Lieb, W.R., Brick, P. Biophys.J. v75 […]

Gyrase: Brittany and Randy

Intro: Gyrase is a protein involved in maintaining the negative supercoiled structure of DNA. It is a two subunit protein and its function in DNA is ATP dependent. Because of its function gyrase is involved in many DNA associated processes including replication, transcription and repair.

DNA Gyrase: Structure and Function Reece, R.J.; Maxwell, A Crit […]

Consurf activity- LHCII- Dmitriy, Keats, Jason

LHCII- Light Harvesting Complex II is part of photosynthesis in higher plants, algae and some bacteria. It is the primary chlorophyll binding protein, andis associated with both of the Photosystems. LHCII also controls the lamellar structure of the thylakoid membrane. It exists as a trimer its natural state composed of a varying combination of three […]

Alcohol Dehydrogenase

Dylan, Ellen, Stephen, and Jerreme

Alcohol Dehydrogenase

Alcohol dehydrogenase (ADH) is an enzyme that catalyzes the conversion of alcohols to aldehydes or ketones and a reduction of NAD+ to NADH. ADH is advantageous to humans because it prevents alcohol toxicity by breaking down alcohol. ADH oxidizes only secondary and tertiary alcohols to aldehydes and ketones […]

Jennifer and Ayla: GFP

Green Fluorescent Protein (GFP)

It’s a protein that glows green when exposed to blue light. It comes from the jellyfish Aequorea victoria. It is often used in experiments as a reporter gene. We chose it because it GLOWS!!!

PBD ID: 2g6e

Sources: http://www.pdb.org/pdb/explore.do?structureId=2G6E# http://www.pdb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb42_1.html

Looked at chain A in jmol

Species source Aequoria victoria (jellyfish), […]