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NCBI Activity: CYP12d1

Cytochrome P450s (CYPs) are found in all organisms and metabolize many xenobiotic chemicals organisms come into contact with everyday. CYP12d1 is found in Drosophila and is known to metabolize DDT. Insecticide resistant strains of Drosophila over-express CYP12d1 along with many other CYP genes.

http://www.connotea.org/

Genome-wide transcription profile of field- and laboratory-selected dichlorodiphenyltrichloroethane (DDT)-resistant Drosophila.

J H F Pedra et al.

Proceedings of the National Academy of Sciences of the United States of America 101 (18), 7034-9 (04 May 2004)

Evaluating the insecticide resistance potential of eight Drosophila melanogaster cytochrome P450 genes by transgenic over-expression.

Phillip J Daborn et al.

Insect biochemistry and molecular biology 37 (5), 512-9 (May 2007)

Expression of Cyp6g1 and Cyp12d1 in DDT resistant and susceptible strains of Drosophila melanogaster.

R A Festucci-Buselli et al.

Insect molecular biology 14 (1), 69-77 (Jan 2005)

For background info see the book:

Cytochrome P450, Michael R. Waterman Elsevier, 1991

Saved Search Parameters:

Limited to full-text articles from the Journals Insect biochemistry and molecular biology & Insect molecular biology from 2005 on with cytochrome p450 as a search term. Alert set up to notify me of new articles being published in these journals on Cytochrome P450s.

Resources:

GoogleBooks is better than NCBI if you want to find books for background info.

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