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ABO Blood Group Frequencies |
The purpose of this excel workbook is to compare several methods for calculating allele frequencies for ABO blood groups. The methods used are the standard textbook approach, the quadratic formula, and the EM algorithm. The user enters the observed numbers of each phenotype. The workbook then uses these to calculate estimates of allele frequencies in Hardy-Weinberg equilibrium for each method. The user can view the formulas used to calculate frequencies through informational buttons. Four forms of graphical output are used to compare each method. Output includes histograms of chi-square values and observed vs. expected phenotype frequencies, as well as a ternary plot of the allele frequencies for each method. Users can also examine a dataset of blood group frequencies for different ethnic groups from Bloodbook.com. |
Source |
Author(s): Published by: BioQUEST Curriculum Consortium OS: win98, win2000, winXP |
User Manuals and Curricular Materials |
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Fundamental Mathematical Concept |
Hardy-Weinberg Equilibrium |
Developed by: |
![]() G.H. Hardy and Wilhelm Weinberg |
Primary Reference |
Boyer, S H, IV, 1963 Papers on Human Genetics. Englewood Cliffs, NJ: Prentice-Hall. Hardy, G. H., 1908 Mendelian proportions in a mixed population. Science 28:49-50. Weinberg, W., 1908 Über den Nachweis der Vererbung beim Menschen. Jahresh. Wuertt. Ver. vaterl. Natkd. 64:369-382. |
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