This worksheet simulates the molecular evolution of DNA sequences. The program begins with a single (random) sequence, then follows that sequence through time as it reproduces and mutates. Eventually, up to 20 evolutionary related sequences are generated. EvolSeq then calculates the genetic distances between each pair of DNA sequences, and also between the associated amino acid sequences.

• Documentation

Neutral Theory of Molecular Evolution

Kimura, M. 1968. "Evolutionary rate at the molecular level". Nature 217: 624-626

Mount D.W. 2001. Bioinformatics: Sequence and Genome Analysis, pp. 237-280. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, New York.

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Kimura, M. 1994. Population Genetics, Molecular Evolution, and the Neutral Theory: Selected Papers, University of Chicago Press.

Lewontin, R. 1974. The Genetic Basis of Evolutionary Change. Columbia University Press.

Ohta, T. 1992. "The nearly neutral theory of molecular evolution". Annual Review of Ecology and Systematics 23: 263-286.

Ohta, T. 1973. "Slightly deleterious mutant substitutions in evolution". Nature 246: 96-98.

Ohta, T. 2002. "Near-neutrality in evolution of genes and gene regulation". Proceedings of the National Academy of Sciences 99: 16134-16137

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Kimura, M. 1991. The neutral theory of molecular evolution: a review of recent evidence. Jpn J Genet 66:367-86.

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Smith, C.M. 2004. CMS Molecular Biology Resource

Holsinger, K. E. The Neutral Theory of Molecular Evolution

Bioinformatics Web 2003.

Golding B. and Morton D. 2003. Elementary Sequence Analysis, chapter 9.

Guttman D.S. 2004. Bio472H1S Computational Genomics and Bioinformatics Course Notes, Feb 4.

Joyce D.E. 1996. Phylogeny and Reconstructing Phylogenetic Trees.

Weston P.H. and Crisp M.D. 1998. Introduction to Phylogenetic Systematics.