This project was prepared as part of a BioQUEST faculty development workshop entitled Evolutionary Bioinformatics Education: A BioQUEST Curriculum Consortium Approach at Indiana State University in March 2004. The BioQUEST Curriculum Consortium is committed to the reform of undergraduate biology instruction through an emphasis on engaging students in realistic scientific practices. This approach is sometimes characterized as an inquiry driven approach and is captured in BioQUEST's three P's (problem-posing, problem-solving, and peer-persuasion). As part of this workshop groups of faculty were encouraged to initiate innovative curricular projects. We are sharing these works in progress in the hope that they will stimulate further exploration, collaboration and development. Please see the following links for additional information:

Upcoming events               BEDROCK Problem Spaces

Bioinformatic Investigation of Insulin Signalling System
Authors          Audiences          Overview           Materials          Resources           Future Directions



Stephen Karr
Carson-Newman College

Joyce Cadwallader
Saint-Mary-of-the-Woods College

Jameel Ahmed
Rose-Hulman Institute of Technology

Janet Clark
Saint-Mary-of-the-Woods College


Possible Audiences:

General Biology Physiology  


Brief Overview:

Use of insulin and insulin receptor as a model system; Compare sequence data for both; Compare structures of each; Use as an example to the more complex cellular signaling mechanism; Use comparison of insulin & receptor sequences as a model for interspecific rates of change (co-evolution).  


Project Materials:

Biology Workbench, PubMed, molecular models  



- Insulin_powerpoint.ppt
- 33930_Preproinsulin.doc
- insulin_receptor_review.pdf