This project was prepared as part of a BioQUEST faculty development workshop entitled Evolutionary Bioinformatics Education: A BioQUEST Curriculum Consortium Approach at Indiana State University in March 2004. The BioQUEST Curriculum Consortium is committed to the reform of undergraduate biology instruction through an emphasis on engaging students in realistic scientific practices. This approach is sometimes characterized as an inquiry driven approach and is captured in BioQUEST's three P's (problem-posing, problem-solving, and peer-persuasion). As part of this workshop groups of faculty were encouraged to initiate innovative curricular projects. We are sharing these works in progress in the hope that they will stimulate further exploration, collaboration and development. Please see the following links for additional information:

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Helix-loop-helix: Simple is not Boring!
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Jennifer Inlow
Indiana State University

Yosi Shibberu
Rose-Hulman Institute of Technology

Larry Merkle
Rose-Hulman Institute of Technology

Barry Muhoberac
Indiana University Purdue University Indianapolis

Chet Fornari
DePauw University


Brief Overview:

Using a common structural motif found in diverse proteins that interact with DNA (such as transcription factors restriction enzymes, and topoisomerases), we explored evolution over taxa for a particular HtH domain-containing protein using CLUSTALW and Phylip. We also explored evolutionary utilization of this motif by different enzymes using BLAST, CLUSTALW, and Domain searches.  



- Figures.ppt
- HtH.ppt
- 19049.CLUSTALW.gif