This project was prepared as part of a BioQUEST faculty development workshop entitled Evolutionary Bioinformatics Education: A BioQUEST Curriculum Consortium Approach at Indiana State University in March 2004. The BioQUEST Curriculum Consortium is committed to the reform of undergraduate biology instruction through an emphasis on engaging students in realistic scientific practices. This approach is sometimes characterized as an inquiry driven approach and is captured in BioQUEST's three P's (problem-posing, problem-solving, and peer-persuasion). As part of this workshop groups of faculty were encouraged to initiate innovative curricular projects. We are sharing these works in progress in the hope that they will stimulate further exploration, collaboration and development. Please see the following links for additional information:

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Molecular Evolution of West Nile Virus
Authors          Audiences          Overview           Materials          Resources           Future Directions



Joann Lau
University of Illinois in Urbana-Champaign

Dave Robinson
Bellarmine University

Charles Johnson
University of Louisville


Possible Audiences:

Farm animals, vectors, avians, people (virologists)  


Brief Overview:

We translated genomic sequences from WNV collected from various animal hosts. CLUSTALW revealed that the horse WNV sequence was the most different. We also added translated genomic sequences from two other related viruses. The region that was most divergent was for a polyprotein precursor.  


Project Materials:

Biology Workbench, NCBI,  



- WestNileEvolution.ppt