This project was prepared as part of a BioQUEST faculty development workshop entitled Bioinformatics in Biology Education: Working with Sequence, Structure and Function at Cornell University in October 2003. The BioQUEST Curriculum Consortium is committed to the reform of undergraduate biology instruction through an emphasis on engaging students in realistic scientific practices. This approach is sometimes characterized as an inquiry driven approach and is captured in BioQUEST's three P's (problem-posing, problem-solving, and peer-persuasion). As part of this workshop groups of faculty were encouraged to initiate innovative curricular projects. We are sharing these works in progress in the hope that they will stimulate further exploration, collaboration and development. Please see the following links for additional information:

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Three isoforms of human tissue plasminogen activator
Authors          Audiences          Overview           Materials          Resources           Future Directions



Anna Tan-Wilson
State University of New York at Binghamton


Possible Audiences:

Class focused on biochemistry or molecular biology  


Brief Overview:

A good example that illustrates alternative splicing while teaching students how to use Mapviewer in NCBI. One can also make this into a lesson on protein domains and how these contribute to catalytic activity, or enhance catalytic activity.  


Project Materials:

Some questions relating to TPA are attached.  


Resources and References:

The following entries as viewed in MapViewer: GenBank NP_000921, GenBank NP_000922, and GenBank NP_127509.  


Future Directions:

I prepared the lesson (attachment) for a class where the main objective is to teach the practical skill of using common programs and databases. I can use this example in Biochemistry and also in Molecular Genetics.  



- Human_TPA.doc