This project was prepared as part of a BioQUEST faculty development workshop entitled Bioinformatics in Biology Education: Working with Sequence, Structure and Function at University of Vermont in April 2003. The BioQUEST Curriculum Consortium is committed to the reform of undergraduate biology instruction through an emphasis on engaging students in realistic scientific practices. This approach is sometimes characterized as an inquiry driven approach and is captured in BioQUEST's three P's (problem-posing, problem-solving, and peer-persuasion). As part of this workshop groups of faculty were encouraged to initiate innovative curricular projects. We are sharing these works in progress in the hope that they will stimulate further exploration, collaboration and development. Please see the following links for additional information:

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Signal transduction molecules
Authors          Audiences          Overview           Materials          Resources           Future Directions



Peter Halbrooks

Peter Wilkinson

Peter Woodruff
Champlain College St-Lambert

Douglas Welsh


Possible Audiences:

Molecular bilogists, biochemists, bioinformaticians  


Brief Overview:

We are interested in molecules that are involved in signal transduction pathways; two-component signal transduction system. Several molecules are found to have sequence similarity. Transcriptional regulatory domains is almost always found associated with the response regulator receiver domain.  


Project Materials:

NCBI protein databank, NCBI domains databank, PDB, BLOCKS Genedoc, Biology workbench, MEME  


Future Directions:

look at evolutionary relationships specifically to the functional domains. Characterise the homology of CHEY in different species and elucidate the structural/functional relationships.  



- AToC_20Chey-like_20receivers.txt
- CheYalign.PDF
- AToC_Alignment_with_Blocks_result.msf