This project was prepared as part of a BioQUEST faculty development workshop entitled Bioinformatics in Biology Education: Working with Sequence, Structure and Function at University of Vermont in April 2003. The BioQUEST Curriculum Consortium is committed to the reform of undergraduate biology instruction through an emphasis on engaging students in realistic scientific practices. This approach is sometimes characterized as an inquiry driven approach and is captured in BioQUEST's three P's (problem-posing, problem-solving, and peer-persuasion). As part of this workshop groups of faculty were encouraged to initiate innovative curricular projects. We are sharing these works in progress in the hope that they will stimulate further exploration, collaboration and development. Please see the following links for additional information:

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Exploring Bioinformatics with Insulin
Authors          Audiences          Overview           Materials          Resources           Future Directions



Linda Grisham
Lesley University

Peter Halbrooks
University of Vermont


Possible Audiences:

pre-service undergrads and in-service teachers  


Brief Overview:

This will be a modification of Bioinformatics exercise developed by Bioquest & EdGrid that focused on hemeglobin. Generative Questions: How do different gene mutations lead to different gene products? Are parts of insulin more highly conserved than others? How can insulin sequences be used to study evolution?  


Project Materials:

Insulin Readings on genetics, insulin, diabetes, and bioinformatics.  


Resources and References:

Bioquest and EdGrid  


Future Directions:

Continue selecting suitable DNA sequences to look at mutations, for alignment, and for phylogentic work. Continue selecting suitable insulin variants whose structure is known to look at the conserved areas  



- Insulin.ppt