This project was prepared as part of a BioQUEST faculty development workshop entitled Structural Bioinformatics at Midwestern Instructional Technology Center in January 2005. The BioQUEST Curriculum Consortium is committed to the reform of undergraduate biology instruction through an emphasis on engaging students in realistic scientific practices. This approach is sometimes characterized as an inquiry driven approach and is captured in BioQUEST's three P's (problem-posing, problem-solving, and peer-persuasion). As part of this workshop groups of faculty were encouraged to initiate innovative curricular projects. We are sharing these works in progress in the hope that they will stimulate further exploration, collaboration and development. Please see the following links for additional information:

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What is the Evolutionary History and Function of GLP-1?
Authors          Audiences          Overview           Materials          Resources           Future Directions



Mary Ritke
University of Indianapolis

Sandra Davis
University of Indianapolis

octavian nicolio
University of Indianapolis

Angela McKinney-Williams
Nebraska Wesleyan University


Possible Audiences:

biology undergraduate students  


Brief Overview:

Both GLP-1 and TrpCage domains are known to be found in the toxin protein, exendin, of the gila monster. In order to determine the evolutionary history of exendin, we chose to create a phylogenetic tree of the GLP-1 (glucagon-like peptide) peptide sequence and map the presence or absence of a second sequence, TrpCage, onto the tree.  


Project Materials:



Resources and References:

NCBI, McVector  


Future Directions:

We were not able to find enough exendin sequences available to test the hypotheses we posed. Therefore, we need to refine the project to make it suitable for classroom use.  



- Presentation1.ppt
- Presentation1.ppt