This project was prepared as part of a BioQUEST faculty development workshop entitled Structural Bioinformatics at Midwestern Instructional Technology Center in January 2005. The BioQUEST Curriculum Consortium is committed to the reform of undergraduate biology instruction through an emphasis on engaging students in realistic scientific practices. This approach is sometimes characterized as an inquiry driven approach and is captured in BioQUEST's three P's (problem-posing, problem-solving, and peer-persuasion). As part of this workshop groups of faculty were encouraged to initiate innovative curricular projects. We are sharing these works in progress in the hope that they will stimulate further exploration, collaboration and development. Please see the following links for additional information:
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biology undergraduate students
Both GLP-1 and TrpCage domains are known to be found in the toxin protein, exendin, of the gila monster. In order to determine the evolutionary history of exendin, we chose to create a phylogenetic tree of the GLP-1 (glucagon-like peptide) peptide sequence and map the presence or absence of a second sequence, TrpCage, onto the tree.
PlayDoh
NCBI, McVector
We were not able to find enough exendin sequences available to test the hypotheses we posed. Therefore, we need to refine the project to make it suitable for classroom use.