This project was prepared as part of a BioQUEST faculty development workshop entitled Bioinformatics in Biology Education: Working with Sequence, Structure and Function at Oklahoma City Community College in January 2005. The BioQUEST Curriculum Consortium is committed to the reform of undergraduate biology instruction through an emphasis on engaging students in realistic scientific practices. This approach is sometimes characterized as an inquiry driven approach and is captured in BioQUEST's three P's (problem-posing, problem-solving, and peer-persuasion). As part of this workshop groups of faculty were encouraged to initiate innovative curricular projects. We are sharing these works in progress in the hope that they will stimulate further exploration, collaboration and development. Please see the following links for additional information:

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Mechanisms of Drug Resistance
Authors          Audiences          Overview           Materials          Resources           Future Directions



Brenda Breeding
Oklahoma City Community College

Nancy Halliday
Southern Nazarene University

Wesley Hanson
Southern Nazarene University


Possible Audiences:

Undergraduate Biology Majors  


Brief Overview:

Understand the relationships between DNA, RNA, and proteins. Explore the effects of tertiary protein structural changes on enzyme function. Learn to utilize tools available in bioinformatics  


Project Materials:

Primary Literature Protein Explorer Biology Workshop  


Resources and References:

Article: Rupp, J. et. al., Serine to asparagine substitution in the gyrase A gene leads to quinolone resistance in moxifloxacin-exposed Chlamydia pneumoniae. Website:  


Future Directions:

This initial exercise is used to introduce the problem space and tools available. Students are then assigned a specific antibiotic resistance model to explore mutations and protein tertiary structure changes that result from these mutations. Students then present results in a professional format.  



- BrendaNancyWesFinal.ppt