This project was prepared as part of a BioQUEST faculty development workshop entitled Mammalian Bioinformatics at Jackson Laboratory in November 2004. The BioQUEST Curriculum Consortium is committed to the reform of undergraduate biology instruction through an emphasis on engaging students in realistic scientific practices. This approach is sometimes characterized as an inquiry driven approach and is captured in BioQUEST's three P's (problem-posing, problem-solving, and peer-persuasion). As part of this workshop groups of faculty were encouraged to initiate innovative curricular projects. We are sharing these works in progress in the hope that they will stimulate further exploration, collaboration and development. Please see the following links for additional information:

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Gene Sleuthing
Authors          Audiences          Overview           Materials          Resources           Future Directions



Majid Masso
George Mason University

Lorraine Sartori
Western New England College

Paul McCreary
Xavier University of Louisiana


Possible Audiences:



Brief Overview:

Search a data base to find a colon cancer gene. Obtain information about the gene. Use Biology Workbench to find the expressed genes protein sequence. Determine the structure of the protein. Use microarray to locate the normal gene.  


Project Materials:

Online software (available through BEDROCK site), Swiss-pdbViewer, micro array tools.  


Resources and References:

See powerpoint slides.  


Future Directions:

See powerpoint slides.  



- geneSleuthing.ppt