This project was prepared as part of a BioQUEST faculty development workshop entitled Modeling in Bioinformatics at Lane Community College in October 2004. The BioQUEST Curriculum Consortium is committed to the reform of undergraduate biology instruction through an emphasis on engaging students in realistic scientific practices. This approach is sometimes characterized as an inquiry driven approach and is captured in BioQUEST's three P's (problem-posing, problem-solving, and peer-persuasion). As part of this workshop groups of faculty were encouraged to initiate innovative curricular projects. We are sharing these works in progress in the hope that they will stimulate further exploration, collaboration and development. Please see the following links for additional information:

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Comparison of p53 Structure: Wild type vs. mutant
Authors          Audiences          Overview           Materials          Resources           Future Directions



Carl Stiefbold
U of Oregon

Pamela Pape-Lindstrom
Everett Community College


Possible Audiences:

Eugene Bedrock Workshop Participants  


Brief Overview:

We compared amino acid sequences of wild-type p53 with a mutant version.  


Project Materials:

Tools Used: Consurf, Protein Data Bank, Google, Biology Workbench, OMIM and NCBI  


Resources and References:

See above  


Future Directions:

Identify the specific amino acid locations in the 1tup and determine if the mutations are in the highly conserved region and indicate these on our figures  



- p53Comparison.ppt