National Science Foundation
                 BioQUEST Curriculum Consortium
Engaging People in Cyberinfrastructure

Application

Evolutionary Bioinformatics:
Globins as a Portal to Exploring Genome Evolution

Opening Activity Data

Globin Gene Server
http://globin.cse.psu.edu/
A database of sequences alignments and experimental results fro the  beta-like gene cluster of mammals.

This site provides data and tools for studying the function of DNA  sequences, with an emphasis on those involved in the production of  hemoglobin. It includes information about naturally-occurring human  hemoglobin mutations and their effects, experimental data related to  the regulation of the beta-like globin gene cluster, and software  tools for comparing sequences with one another to discover regions  that are likely to play significant roles.

See the following for more info:

Globin PowerPoint by Sam Donovan

http://globin.cse.psu.edu/html/sample-align.html

http://globin.cse.psu.edu/html/conserved/index.html
     set of tools for finding conserved regions in alignments

http://globin.cse.psu.edu/html/dna-sequences.html

Molecule of the month at PDB

Hemoglobin
http://www.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb41_1.html

Myoglobin
http://www.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb1_1.html


Globin Gene Labs
http://www.muhlenberg.edu/depts/biology/courses/bio152/BioinformaticsLab/index.html


SUPERFAMILY globin
http://pir.georgetown.edu/ (Search for Globin)


References

Bashford, D., Chothia, C., and Lesk, A. M. (1987). Determinants of a  protein fold: Unique features of the globin bamino acid sequences. J.  Mol. Biol., 196:199-216.

Hardison, Ross.  Hemoglobins from Bacteria to Man: Evolution of
Different Patterns of Gene Expression.
http://jeb.biologists.org/cgi/reprint/201/8/1099

Hemoglobin_A2_Origin_Evolution_Aftermath.pdf

Porphyrin_Rings.pdf

The_Evolution_of_Hemoglobin.pdf


Sponsored by a grant from the National Science Foundation (DUE/CCLI-ND)
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