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Application |
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Prion biology problem space: Mad cows, itchy sheep and protein structure
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Tools presented in the problem space can be used for in-class projects in introductory biology classes. More complex questions could be carried from introductory biology to more advanced biochemistry, molecular biology and evolution classes. Undergraduate students could also use this as a starting point to develop independent research projects. |
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Prions are infectious protein particles associated with various neurodegenerative diseases in humans and animals. This problem space introduces basic skills in protein structure and sequence exploration that can be used to analyze some unusual properties of prions, and develop testable hypotheses that can be explored through these tools. Students will be challenged to use a systems-biology approach to link structure, evolution and function of proteins. |
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Power Point Presentation: Prion Problem Space: Mad cows, itchy sheep and protein structure? |
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1. GeneDoc software for sequence analysis from http://www.psc.edu/biomed/genedoc/
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We plan to impliment this activity in two classrooms this academic year. |
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