This investigative case module was prepared as part of a BioQUEST faculty development workshop entitled NSF Chautauqua Short Course: Investigative Cases at Christian Brothers University in July 2004. The cases, resources, and implementation strategies were developed by participants for use with their own students. We invite you to adopt and adapt the following materials.

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Investigative Cases
   
The Case: Hair Today...

Part 1

"Damn!" Joe said, walking out of the bathroom. "Look at all this hair in my comb."

His roommate looked up from the computer. "So?"

“By the time I graduate I’m gonna look like my dad.”

“Sucks to be you, man. I’ve seen your dad. But I thought you were supposed to get baldness from your mom.”

“My mom’s not bald!”

“No, I mean like her side of the family, moron. Got any bald uncles?”

“Just my uncle Frank… but he’s Dad’s brother.”

“I don’t know. Maybe you’re a mutant.”

Part 2:

“Hey, I saw your dad at graduation, Joe. Was that a rug, or does he really have hair now?”

“Weird, huh? The doctor gave him a prescription for some drug for baldness, and he grew a bunch of hair."
“What drug? Like Rogaine?”

“No, It’s called Propecia – it lowers his testosterone or something.”

“Whoa – so is he gonna start, you know, singing soprano now?”

”Not that I’ve noticed. You’re right, though, it sounds kinda scary.”

Part 3

“Hey, mutant!”

Joe looked up as his roommate walked in. “Ha ha.”

“No, really, my girlfriend has a job in a lab in the biology department, and they have these mice that don’t have any hair at all. I bet they have the same mutation that bald people like you have.”

“Right. I still have a lot of hair. And even really bald people have eyebrows, you know. Besides, people aren’t mice.”

“So? Mice are mammals, people are mammals – probably have the same genes.”

Case Author:
Allen Gathman Southeast Missouri State University

Case Analysis

Part 1:

How is baldness inherited?

Is baldness sex-linked?

Why do males show baldness and females not?

Part 2:

How does Propecia work?

How does Rogaine work?

Does Propecia lower your testosterone?

How is testosterone connected to hair loss?

What side effects are there from Propecia?

Part 3:

Is there a gene in humans like mouse "hairless?" How closely related are humans and mice?

Option: Include a know / need to know chart like the one below:

What do you know?
What do you need to know?
   

Learning Goals

Goal(s)

Understanding of sex linkage and sex influence.

Understanding of hormone effects on gene regulation.

Ability to locate information in OMIM.

Ability to align sequences and make trees with ClustalW.

Standards

 

Investigations and Activities

After the first part, students construct a know/need to know table, then search using some suggested pages (see resources below) for information on the web and in textbook.

 

Resources

OMIM (use workbench) - alopecia, androgenetic (and others)

AMA information on male pattern baldness

Steroid hormone receptors

Ellis et al., article about Androgenetic Alopecia Propecia:

Look it up on RxList



http://www.people.virginia.edu/~rjh9u/genereg.html

Students will usually obtain additional references or resources
to help answer or explore their questions.

Special Data Items

>mouse_hr 1 MESMPSFLKD TPAWEKTAPV NGIVGQEPGT SPQDGLRHGA LCLGEPAPFW RGVLSTPDSW 61 LPPGFLQGPK DTLSLVEGEG PRNGERKGSW LGGKEGLRWK EAMLAHPLAF CGPACPPRYG 121 PLIPEHSGGH PKSDPVAFRP LHCPFLLETK ILERAPFWVP TCLPPYLMSS LPPERPYDWP 181 LAPNPWVYSG SQPKVPSAFG LGSKGFYHKD PNILRPAKEP LAESGMLGLA PGGHLQQACE 241 SEGPSLHQRD GETGAGRQQN LCPVFLGYPD TVPRAPWPSC PPGLVHSLGN IWAGPGSNSL 301 GYQLGPPATP RCPSPGPPTP PGGCCSSHLP AREGDLGPCR KCQDSPEGGS SGPGESSEER 361 NKADSRACPP SHHTKLKKTW LTRHSEQFEC PGGCSGKEES PATGLRALKR AGSPEVQGAS 421 RGPAPKRPSH PFPGTGRQGA RAWQETPETI IGSKAEAEQQ EEQRGPRDGR IRLQESRLVD 481 TSCQHHLAGV TQCQSCVQAA GEVGVLTGHS QKSRRSPLEE KQLEEEDSSA TSEEGGGGPG 541 PEASLNKGLA KHLLSGLGDR LCRLLRKERE ALAWAQREGQ GPAMTEDSPG IPHCCSRCHH 601 GLFNTHWRCS HCSHRLCVAC GRIAGAGKNR EKTGSQEQHT DDCAQEAGHA ACSLILTQFV 661 SSQALAELST VMHQVWAKFD IRGHCFCQVD ARVWAPGDGG QQKEPTEKTP PTPQPSCNGD 721 SNRTKDIKEE TPDSTESPAE DGAGRSPLPC PSLCELLAST AVKLCLGHDR IHMAFAPVTP 781 ALPSDDRITN ILDSIIAQVV ERKIQEKALG PGLRAGSGLR KGLSLPLSPV RTRLSPPGAL 841 LWLQEPRPKH GFHLFQEHWR QGQPVLVSGI QKTLRLSLWG MEALGTLGGQ VQTLTALGPP 901 QPTNLDSTAF WEGFSHPETR PKLDEGSVLL LHRTLGDKDA SRVQNLASSL PLPEYCAHQG 961 KLNLASYLPL GLTLHPLEPQ LWAAYGVNSH RGHLGTKNLC VEVSDLISIL VHAEAQLPPW 1021 YRAQKDFLSG LDGEGLWSPG SQTSTVWHVF RAQDAQRIRR FLQMVCPAGA GTLEPGAPGS 1081 CYLDAGLRRR LREEWGVSCW TLLQAPGEAV LVPAGAPHQV QGLVSTISVT QHFLSPETSA 1141 LSAQLYHQGA SLPPDHRMLY AQMDRAVFQA VKAAVGALQE AK

>rat_hr

1 MGLRSSCFVL TLQDPPLGEP HEGRRVMESM PSFLKDTPAW EKTAPVNGIV GQEPGTSPQD 61 GLHHGALCLG EPVPFWRGVL SAPDSWLPPG FLQGPKDTLS VVEGEGSRNG ERKANWLGSK 121 EGLRWKEAML AHPLAFCGPA CPPRYGPLIP EHSSGHPKSD PVAFRPLHCP FLLETKILER 181 APFWVPTCLP PYLMSSLPPE RSYDWPLAPS PWVYSGSQPK VPSAFSLGSK GFYHKDPNIL 241 RPAKEPLAAS ESGMLGLAPG GHLQQACDAE GPSLHQRDGE TGAGRQQNLC PVFLGYPDTV 301 PRTPWPSCPP GLVHTLGNVW AGPGSNSFGY QLGPPVTPRC PSPGPPTPPG GCCSSHLPAR 361 EGDPGPCRKC QDSPEGSSSG PGESSEERNK AGSRASPPSH HTKLKKTWLT RHSEQFECPG 421 GCPGKGESPA TGLRALKRAG SPEVQGARGP APKRPSHTFP GTGRQGARAW QETPETSTGS 481 KAEAQQQEEQ RGPRDGRIRL RESRLEDTSC QHHLAGVTQC PSCVQAAGEV EILTSHSQKS 541 HKLPLEEKPL EEDSCATSEE GGGSSPEASI NKGLAKHLLS GLGDRLCRLL RKEREALAWA 601 QREGQGPAMT EDSPGIPHCC SRCHHGLFNT HWRCSHCSHR LCVACGRIAG AGKNREKTGS 661 REQRTDDCAQ EAGHAACSLI LTQFVSSQAL AELSTVMHQV WAKFDIRGHC FCQVDARVWA 721 PGDGGQQKEP TEKTPPAPQL SCNGDSNRTK DIKEETPDST ESPAEDRAGR SPLPCPSLCE 781 LLASTAVKLC LGHERIHMAF APVTPALPSD DRITNILDSI IAQVVERKIQ EKALGPGLRA 841 GSGLRKGLSL PLSPVRTQLS PPGALLWLQE PRPKHGFRLF QEHWRQGQPV LVSGIQKTLR 901 LSLWGMEALG TLGGQVQTLT ALGPPQPTSL DSTAFWKGFS HPEARPKLDE GSVLLLHRPL 961 GDKDESRVEN LASSLPLPEY CAHQGKLNLA SYLPLGLTLH PLEPQLWAAY GVNSHRGHLG 1021 TKNLCVEVSD LISILVHAEA QLPPWYRAQK DFLSGLDGEG LWSPGSQTST VWHVFRAQDA 1081 QRIRRFLQMV CPAGAGTLEP GAPGSCYLDS GLRRRLREEW GVSCWTLLQA PGEAVLVPAG 1141 APHQVQGLVS TISVTQHFLS PETSALSAQL CHQGASLPPD HRMLYAQMDR AVFQAVKVAV 1201 GTLQEAK

>human_hr
1 MESTPSFLKG TPTWEKTAPE NGIVRQEPGS PPRDGLHHGP LCLGEPAPFW RGVLSTPDSW 61 LPPGFPQGPK DMLPLVEGEG PQNGERKVNW LGSKEGLRWK EAMLTHPLAF CGPACPPRCG 121 PLMPEHSGGH LKSDPVAFRP WHCPFLLETK ILERAPFWVP TCLPPYLVSG LPPEHPCDWP 181 LTPHPWVYSG GQPKVPSAFS LGSKGFYYKD PSIPRLAKEP LAAAEPGLFG LNSGGHLQRA 241 GEAERPSLHQ RDGEMGAGRQ QNPCPLFLGQ PDTVPWTSWP ACPPGLVHTL GNVWAGPGDG 301 NLGYQLGPPA TPRCPSPEPP VTQRGCCSSY PPTKGGDLGP CGKCQEGLEG GASGASEPSE 361 EVNKASGPRA CPPSHHTKLK KTWLTRHSEQ FECPRGCPEV EERPVARLRA LKRAGSPEVQ 421 GAMGSPAPKR PPDPFPGTAE QGAGGWQEVR DTSIGNKDVD SGQHDEQKGP QDGQASLQDP 481 GLQDIPCLAL PAKLAQCQSC AQAAGEGGGH ACHSQQVRRS PLGGELQQEE DTATNSSSEE 541 GPGSGPDSRL STGLAKHLLS GLGDRLCRLL RREREALAWA QREGQGPAVT EDSPGIPRCC 601 SRCHHGLFNT HWRCPRCSHR LCVACGRVAG TGRAREKAGF QEQSAEECTQ EAGHAACSLM 661 LTQFVSSQAL AELSTAMHQV WVKFDIRGHC PCQADARVWA PGDAGQQKES TQKTPPTPQP 721 SCNGDTHRTK SIKEETPDSA ETPAEDRAGR GPLPCPSLCE LLASTAVKLC LGHERIHMAF 781 APVTPALPSD DRITNILDSI IAQVVERKIQ EKALGPGLRA GPGLRKGLGL PLSPVRPRLP 841 PPGALLWLQE PQPCPRRGFH LFQEHWRQGQ PVLVSGIQRT LQGNLWGTEA LGALGGQVQA 901 LSPLGPPQPS SLGSTTFWEG FSWPELRPKS DEGSVLLLHR ALGDEDTSRV ENLAASLPLP 961 EYCALHGKLN LASYLPPGLA LRPLEPQLWA AYGVSPHRGH LGTKNLCVEV ADLVSILVHA 1021 DTPLPAWHRA QKDFLSGLDG EGLWSPGSQV STVWHVFRAQ DAQRIRRFLQ MVCPAGAGAL 1081 EPGAPGSCYL DAGLRRRLRE EWGVSCWTLL QAPGEAVLVP AGAPHQVQGL VSTVSVTQHF 1141 LSPETSALSA QLCHQGPSLP PDCHLLYAQM DWAVFQAVKV AVGTLQEAK

>macaque_hr
1 MESSPSFLKG TWEKTAPENG IVRQEPGSPP RDGLHRGPLC LGEPAPFWGG IPSTPDSWLP 61 PGFPQGPKDT LPLVEGEGPQ NGERKVNWLG SKEGLRWKEA MLTHPLAFCG PACPPRCGPL 121 MPEHSGGHLK SDPVAFRPWH CPFLLETKIL ERAPFWVPTC LPPYVVSGLP PERPCDWPLA 181 PHPWVHSGGQ PKVPSAFSLG SKGFYYKDPS IPRLAKEPLA AAEPGLFGLN SGGHLQRAGE 241 AERPSLHQRD GEMGAGRQQN PCPLFLGQPD TVPWTSWPAC PPGLVHTLGN VWAGPSGGSL 301 GYQLGPPTTP RCPSPEPPIT QRGCCSSYPP IKDGGLGPCG KCQEGLDGVA SGASEPSEEV 361 NKASGPRACP PGHHTKLKKT WLTRHSEQFE CPRGCPEAEE RPVAQLRALK RAGSPEIQGA 421 VGGPAPKRPP DPFPGTAEQG AGGWQEVRDT SIGNKEADSG QHDDQRGPRD GQASLQDPGL 481 QEIPCLALPA KLAQCQSCAQ AAGEGGGPAG HFQQVRRSPL GGELQQEEDT AANSSSEEGP 541 GSGPDGRLST GLSKHLLSSL GDRLCRLLRR EREALAWAQR EGQGPAVTED NPGIPRCCSR 601 CHHGLFNTHW RCPRCSHRLC VACGRVAGAG RAREKAGSRE QSTEECTQEA GHAACSLTLT 661 QFVSSQALAE LSTAMHQVWV KFDIRGHCPC QADARVWAPG DAGQQKESTQ KTPPTPQPSC 721 NGDTHRTKSI KEETPDSTET PAEDRAGQAP LPCPSLCELL ASTAVKLCLG HERIHMAFAP 781 VTPALPSDDR ITNILDSIIA QVVERKIQEK ALGPGLRAGP GLRKGLGLPL SPVRPRLPPP 841 GALLWLQEPR PRPQRGFHLF QEHWRQGQPV LVSGIQRTLQ GNLWGTEALG ALGGQVQALS 901 PLGPPQPTSL GSTAFWEGFS WPELRPKSDE GSVLLLHRAL GDEDTSRVEN LAASLPLPEY 961 CAHRGKLNLA SYLPPGLALR PLEPQLWAAY GVSPHRGHLG TKNLCVEVAD LVSILVHADT 1021 PLPAWHRAQK DFLSGLDGEG LWSPGSQVST VWHVFRAQDA QRIRRFLQMV CPAGAGALEP 1081 GAPGSCYLDA GLRRRLREEW GVSCWTLLQA PGEAVLVPAG APHQVQGLVS TVSVTQHFLS 1141 PETSALSAQL CHQGPSLPPD CHLLYAQMDW AVFQAVKVAV GTLQEAK

>sheep_hr_partial
1 MESTPSFPKD IPAWEKTAPE NGIAGRDLDT PPRDGLRPAA LCLGEPAPFW RGVLSTPGSW 61 LPPGFPQSPK DTLPLVEGEG PRNGERKPGW PSSKDGLRWK EAMLTHPLAF CGSPCPPRYS 121 PLDPEHNGGH PKSDPVAFRP LHCPFLLETK ILERAPFWMP TCLPPYLVSS LPPEHPCDWP 181 LAPHPWVYSG GQPKVPSAFS LGSKGFYHKD PSILRLAKDP LATVEPGLLG SAPRGHLQRT 241 GEVEHPTLHQ RDGETGVGRH PNLCPLLLGH PDTVARTPWP TCSPGLVHTL GNVWAVPGGG 301 SLGYQLGPSA ATRCPSPGPP TTQAGYCSSH PPARDDPCGQ CQEDLEGATS EPSESSEEAY 361 KTPSPRACLP SHHTKLKKTW LTRHSEQFGC PDSCPGEEES PAAQLPARKR SSSPEVQGTA 421 SSPAAKRPTG PFPGSVGQGA RGRQEVLDSV FGNKAETEQR DDHRGPRDDG ASLQAPGPQD 481 TPGVPPVAGI TQCQGCAQAA GETGGPAHYS QPLSRLLLGG EQPQEEDSAA SSKEGGGSGP 541 EAGLSVGLAK HLLSALGDRL CRVLRREREA LVWAHQEGQA PVGTEDDPSL PRCCSHCHHG 601 LFNTHWRCPR CSHRLCVTCG RMAGAGSTRE KAGSQGQSTE KCGQEAGHSA GSLMLTQFVS 661 SQPLAELSAA MHQVWVKFDI RGHCPCQADA RVWTAGDGGL QKEPTEKTP

>pig_hr_partial
1 PGLRKGLGLP LSPVRLRLPP PGPLLWLQEP RPQRGFHLFQ EHWRQGQPVL VSGIQKTLQS 61 HLWETEALGA LGGQVHALTP LGPPQSTSLG STAFWEGFSR PETRPKSDEG SVLLLHRALG 121 DEDASRVENL AASLPLPEYC AHHGKLNLAS YLPPGPGLRP LVPQIWAAYG VSPHRGHLGT 181 KNLCVEVTSL VSVLVRAEAP LPTWHRAQKD FLSGLDGEGL WSPGSQVSTV WHVFRAQDTQ 241 RIRRFLQMVC PAGAGNLEPG TPGSCYLDAR LRRRLREEWG VSCWTLLQAP GEAVLVPAGA 301 PHQVQGLVST VSITQHFLSP ETSALSTQLC HQGPSLPLMP PA

1. gnrganim.gif
2. propecia.gif
3. iP1010015BurmeseHairless.jpg
4. proped.gif
5. propeciacartoon.gif

 

Student Products

Part 1 --

Students will work in groups using OMIM and other online resources and submit short written reports on types of baldness and their inheritance.

Each group will receive a pedigree for a specific type of baldness or related condition and determine its mode of inheritance. Each group will give a poster presentation explaining their conclusions for their pedigree.

Example: Alopecia universalis: http://www.people.virginia.edu/~rjh9u/proped.html

Part 2 --

Groups will use web resources to find the mode of action of Propecia. Each group will prepare a brochure showing how Propecia works, what the side effects can be, and who should and should not take it.

Each group will look for other genes regulated by steroid hormones and choose one to report on.

Part 3 --

Working in groups, students will be given a data set of hairless homologs from GenBank. They will use ClustalW to align them and produce trees, and then draw conclusions. They will present results in poster form.

Assessment and Evaluation Plan

Posters from parts 1 and 3 will be presented to the class by each group. They will be peer and instructor evaluated, using sheets with a scoring rubric including completeness, clarity, and correctness.

Brochures will be graded by the instructor.

Content knowledge and understanding of concepts will be assessed in an exam at the end of the unit.

 

Implementation

This unit will be introduced in three successive lectures, with time in class for group work. Group presentations will occur in successive class periods.

Course name:
Genetics
Likely sequence in syllabus:
At beginning of eukaryotic gene regulation unit.
Time during term:
8th week.
Duration:
Three successive lecture periods
Setting:
Lecture/discussion in room with movable chairs.
Students in course:
30
Collaborative elements:
Additional notes:

 

Credits

http://www.cashfever.com/propecia/

http://www.usuhs.mil/cehto/images/propecia.gif

http://www.uq.net.au/~zzpbolit/photogalleryother.html

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