Investigative Case 10:  SHH- Silencing the Hedgehog Pathway

Open-Ended Investigations

To learn more about the hedgehog pathway, you could explore the Hedgehog Pathway Signaling Database (Ramirez-Weber, 2006), which contains relevant information, images, and references to research articles. You may wish to form a group to develop a proposal for a new investigation. For example:

Note: Your instructor could set up a proposal peer review process in your class, simulating what is done by major funders such as the National Science Foundation and the National Institutes of Health.

Other links of use for projects:

Stem cell basics: What are the potential uses of human stem cells and the obstacles that must be overcome before these potential uses will be realized? In Stem Cell Information [World Wide Web site]. Bethesda, MD: National Institutes of Health, U.S. Department of Health and Human Services, 2006.

Athar, Mohammad, Chengxin Li , Xiuwei Tang, Sumin Chi, Xiaoli Zhang, Arianna L. Kim, Stephen K. Tyring, Levy Kopelovich, Jennifer Hebert, Ervin H. Epstein Jr., David R. Bickers, and Jingwu Xie. Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis. Cancer Research 64:7545–7552, 2004.


Chen, James K., Jussi Taipale, Michael K. Cooper, and Philip A. Beachy. Inhibition of hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes and Development, 16:2743–2748, 2002.

Matlack, D., P. Pape-Lindstrom, and S. Webb. Hedgehog-emony: BioQUEST Complex Data Sets Workshop Project.

Ramirez-Weber, F. A. The Hedgehog Signaling Pathway Database. NIH RIMI 5P20-MD000262. San Francisco State University.

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