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Deme 2.0

This workbook simulates the population genetics of a single gene with two alleles. It can simultaneously model up to three local populations, which may differ in their selection coefficients.


Tony Weisstein, Truman State University

Published by: BioQUEST Curriculum Consortium


User Manuals and Curricular Materials
Popular Text Citations

Snustad D P, Simmons M J (2003) Principles of Genetics. 3rd Edition. New York : John Wiley & Sons, Inc.

Crow J F (1986) Basic Concepts in Population, Quantitative, and Evolutionary Genetics. New York : W. H. Freeman and Company.

Li C C (1955) Population Genetics. Chicago : University of Chicago Press.

Freeman S. and Herron J. C. 2004. Evolutionary Analysis, 2nd edition. Pearson Prentice Hall: Upper Saddle River, New Jersey.

Research Articles

Marmor M., Sheppard H.W., Donnell D., et al. 2001. Homozygous and heterozygous CCR5-(delta)32 genotypes are associated with resistance to HIV infection. J. Acquir. Immune Defic. Syndr. 27: 472-481.

Kokkotou E., Philippon V., Gueye-Ndiaye A., et al. 1998. Role of the CCR5 delta 32 allele in resistance to infection in west Africa. J. Hum. Virol. 1: 469-474.

Wellek S, 2004 Tests for establishing compatibility of an observed genotype distribution with Hardy-Weinberg Equilibrium in the case of a biallelic locus. Biometrics 60: 694-703.

Wittke-Thompson JK, Pluzhnikov A, Cox NJ, 2005 Rational inferences about departures from Hardy-Weinberg equilibrium. American Journal of Genetics 76: 967-86.

Hosking L, Lumsden S, Lewis K, Yeo A, McCarthy L, Bansal A, Riley J, Purvis I, Xu CF, 2004 Detection of genotyping errors by Hardy-Weinberg equilibrium testing. European Journal of Human Genetics 12: 395-9.

Education Research & Pedagogical Materials

Kaplan R. 1997. PopBio.

Alstad D.N. 2003. Populus 5.3.

Genes, Environment, and Human Behavior. Biological Sciences Curriculum Study (BSCS), 152pp

Louisiana State University. 2000. Software for Population Genetic Analyses.

Price F. and Vaughan V. 1998. EVOLVE. In The BioQUEST Library, Vol. VI (Jungck J.R., Calley J.N., Donovan S., Everse S.J., Soderberg P., Stanley E., Stewart J., eds). Academic Press: San Diego, CA.

Soderberg P. and Price F. 2003. An examination of problem-based teaching and learning in population genetics and evolution using EVOLVE, a computer simulation. Int. J. Sci. Educ. 25: 35-55.

Tutorial & Background materials

The Hardy-Weinberg Equilibrium by John W. Kimball

Weisstein Tony () Deme 2.0. A module of the Biological ESTEEM Collection, published by the BioQUEST Curriculum Consortium. URL: