This workbook simulates the population genetics of a single gene with two alleles. It can simultaneously model up to three local populations, which may differ in their selection coefficients.

• Documentation

Hardy and Weinberg Equilibrium

Weinberg, W., 1908 Über den Nachweis der Vererbung beim Menschen. Jahresh. Wuertt. Ver. vaterl. Natkd. 64:369-382.

Hardy, G. H., 1908 Mendelian proportions in a mixed population. Science 28:49-50.

Snustad D P, Simmons M J (2003) Principles of Genetics. 3rd Edition. New York : John Wiley & Sons, Inc.

Crow J F (1986) Basic Concepts in Population, Quantitative, and Evolutionary Genetics. New York : W. H. Freeman and Company.

Li C C (1955) Population Genetics. Chicago : University of Chicago Press.

Freeman S. and Herron J. C. 2004. Evolutionary Analysis, 2nd edition. Pearson Prentice Hall: Upper Saddle River, New Jersey.

Marmor M., Sheppard H.W., Donnell D., et al. 2001. Homozygous and heterozygous CCR5-(delta)32 genotypes are associated with resistance to HIV infection. J. Acquir. Immune Defic. Syndr. 27: 472-481.

Kokkotou E., Philippon V., Gueye-Ndiaye A., et al. 1998. Role of the CCR5 delta 32 allele in resistance to infection in west Africa. J. Hum. Virol. 1: 469-474.

Wellek S, 2004 Tests for establishing compatibility of an observed genotype distribution with Hardy-Weinberg Equilibrium in the case of a biallelic locus. Biometrics 60: 694-703.

Wittke-Thompson JK, Pluzhnikov A, Cox NJ, 2005 Rational inferences about departures from Hardy-Weinberg equilibrium. American Journal of Genetics 76: 967-86.

Hosking L, Lumsden S, Lewis K, Yeo A, McCarthy L, Bansal A, Riley J, Purvis I, Xu CF, 2004 Detection of genotyping errors by Hardy-Weinberg equilibrium testing. European Journal of Human Genetics 12: 395-9.

Kaplan R. 1997. PopBio.

Alstad D.N. 2003. Populus 5.3.

Genes, Environment, and Human Behavior. Biological Sciences Curriculum Study (BSCS), 152pp

Louisiana State University. 2000. Software for Population Genetic Analyses.

Price F. and Vaughan V. 1998. EVOLVE. In The BioQUEST Library, Vol. VI (Jungck J.R., Calley J.N., Donovan S., Everse S.J., Soderberg P., Stanley E., Stewart J., eds). Academic Press: San Diego, CA.

Soderberg P. and Price F. 2003. An examination of problem-based teaching and learning in population genetics and evolution using EVOLVE, a computer simulation. Int. J. Sci. Educ. 25: 35-55.

The Hardy-Weinberg Equilibrium by John W. Kimball