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Development of a bioinformatics project for high school laboratories
 
 
Authors          Audiences          Overview           Materials          Resources           Future Directions
 

 


Authors


David Ely
Champlain Valley Union High School


Peter Woodruff
Champlain College - St. Lambert


Nan Mason
University of Vermont


Mary Tierney
University of Vermont

 
   
 


Possible Audiences:

high school students two-year college biology students  

 
 


Brief Overview

The goal of this project was to let students use the tools available at NCBI to investigate the how mutation of certain proteins could lead to cancer. Possible proteins to investigate might be p53 and ras. Much of this has been worked out for p53, and this information can be accessed at http://www.iarc.fr/p53. A slide show at this web site can be used as introductory material for the types of information that can be determined for a protein associated with a number of cancers. Students could then use the NCBI web site to ask similar questions about ras.  

 
   
 


Project Materials

Tools on the NCBI web site (i.e. structure with PDB). Amino acid sequence and structure can be compared for the wild type and mutant form of these proteins.  

 
 


Resources and References

 

 
   
 


Future Directions

Similar approaches to be taken for looking at amino acid sequences for wild type and mutant proteins involved in cancer of other physiological/developmental processes. This type of exercise would emphasize structure/function relationships between proteins and the effect of mutations on cell physiology and/or cell division.  

 
 


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