Bioinformatics Education Dissemination: Reaching Out, Connecting and Knitting-together

Introduction to the HIV Problem Space

This problem space contains data from a published study by Markham et al on HIV evolution within individual patients. The study involved 15 injection drug users in Baltimore, Maryland (USA) who became infected with HIV between 1989 and 1992. Patients came in at approximately six-month intervals ("visits") to have blood samples taken. From these samples, the researchers extracted and sequenced multiple copies of proviral DNA. Patients' CD4 counts were also measured at each visit to assess their level of immune function.

In this problem space, you will have access to the following materials:

You can use this data to explore a number of different questions. Here are a few general questions to get you started: