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Differential gene expression in breast carcinoma
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Upper-level undergraduate courses in biochemistry, molecular biology or genetics |
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Working on gene expression data available on the web, students can determine which genes are up-regulated. Each of those individual genes are linked to GO. This work can be preceded by a discussion of what sets of genes students think will be up-regulated in cancer vs normal tissue. |
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The differential gene expression data acquired by the technique, SAGE (Serial Analysis of Gene Expression) is intuitive. They can elect to display all the genes that are up-regulated in normal vs cancer tissue, or the other way around. Clicking on Gene Info gives information about the gene, including links to the GO annotation. |
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http://cancerres.aacrjournals.org/cgi/content/full/61/15/5697 |
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