This project was prepared as part of a BioQUEST faculty development workshop entitled ASM/BioQUEST Bioinformatics Institute at American Society for Microbiology in March 2008. The BioQUEST Curriculum Consortium is committed to the reform of undergraduate biology instruction through an emphasis on engaging students in realistic scientific practices. This approach is sometimes characterized as an inquiry driven approach and is captured in BioQUEST's three P's (problem-posing, problem-solving, and peer-persuasion). As part of this workshop groups of faculty were encouraged to initiate innovative curricular projects. We are sharing these works in progress in the hope that they will stimulate further exploration, collaboration and development. Please see the following links for additional information:
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Background: Chemotaxis in bacteria involves methyl accepting chemotaxis receptor proteins (MCP) that sense the attractants and repellents in the environment and interact with a histidine kinase CheA initiating a phosphorylation cascade that affects flagellar rotation. Hypothesis: Proteins associated with chemotaxis will be differentially selected in pathogenic species compared to free-living representatives. We compared the MCPs and CheA proteins in species of pathogenic and a free-living Bordetella species.
Biology Workbench ConSurf Server BLAST NCBI Microbial Genomes
Transporter repetoire; evolution of CheA across more taxa