This project was prepared as part of a BioQUEST faculty development workshop entitled Evolutionary Bioinformatics Education: A BioQUEST Curriculum Consortium Approach at NSF Chautauqua Short Course in May 2003. The BioQUEST Curriculum Consortium is committed to the reform of undergraduate biology instruction through an emphasis on engaging students in realistic scientific practices. This approach is sometimes characterized as an inquiry driven approach and is captured in BioQUEST's three P's (problem-posing, problem-solving, and peer-persuasion). As part of this workshop groups of faculty were encouraged to initiate innovative curricular projects. We are sharing these works in progress in the hope that they will stimulate further exploration, collaboration and development. Please see the following links for additional information:

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The highly conserved coronavirus RNA polymerase and SARS
Authors          Audiences          Overview           Materials          Resources           Future Directions



Jim Hewlett
Finger Lakes Community College


Possible Audiences:

Freshman Biology Course; Intro Biotechnology courses teaching bioinformatics  


Brief Overview:

RNA polymerase from coronavirus from a variety of different hosts are compared to sequences obtained from strains of the new SARS virus from Hong Kong, Vietnam and North America.  


Project Materials:



Resources and References:

Stephensen CB, Casebolt DB, Gangopadhyay NN. 1999. Phylogenetic analysis of a highly conserved region of the polymerase gene from 11 coronaviruses and development of a consensus polymerase chain reaction assay. Virus Res 60(2):181-9.  



- sequences.txt
- tree.jpg
- coronavirus.pdf
- SARS.pdf