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Mechanisms of Drug Resistance
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Undergraduate Biology Majors |
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Understand the relationships between DNA, RNA, and proteins. Explore the effects of tertiary protein structural changes on enzyme function. Learn to utilize tools available in bioinformatics |
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Primary Literature Protein Explorer Biology Workshop |
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Article: Rupp, J. et. al., Serine to asparagine substitution in the gyrase A gene leads to quinolone resistance in moxifloxacin-exposed Chlamydia pneumoniae. Website: www.ncbi.nlm.nih.gov |
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This initial exercise is used to introduce the problem space and tools available. Students are then assigned a specific antibiotic resistance model to explore mutations and protein tertiary structure changes that result from these mutations. Students then present results in a professional format. |
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