1. You have been asked to research HIV-2 in order to find some areas of the envelope protein which could be targeted for researching treatments. As we learned earlier, HIV-2 has been found to be prevalent in populations where people on average have far fewer sexual partners than in populations where HIV-1 is prevalent. First, outline the steps you would take in order to solve this problem. Second, offer a possible prediction of how HIV-2 mutation rates would compare to HIV-1 based on what you know about the two viruses.
2. A mutation found in the protein hemoglobin causes the condition known as sickle cell anemia. Outline below how you would find out where this mutation is located on the protein’s amino acid sequence, and how you would figure out what kind of mutation is responsible for the condition (i.e. substitution, deletion, insertion…).