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Show Me the Way to Go Home: Evolution of chemotaxis proteins MCP and CheA in the transition from a free-living to pathogenic life style in Bordetella
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Background: Chemotaxis in bacteria involves methyl accepting chemotaxis receptor proteins (MCP) that sense the attractants and repellents in the environment and interact with a histidine kinase CheA initiating a phosphorylation cascade that affects flagellar rotation. Hypothesis: Proteins associated with chemotaxis will be differentially selected in pathogenic species compared to free-living representatives. We compared the MCPs and CheA proteins in species of pathogenic and a free-living Bordetella species. |
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Biology Workbench ConSurf Server BLAST NCBI Microbial Genomes |
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Transporter repetoire; evolution of CheA across more taxa |
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